DEPARTMENT OF ORTHOPAEDIC SURGERY

  • GREETING
  • STAFF
  • SPINE AND SPINAL CORD DIVISION
  • UPPER EXTREMITY DIVISION
  • LOWER EXTREMITY DIVISION
  • ORTHOPAEDIC ONCOLOGY DIVISION
  • BASIC AND LABORATORY
  • RESIDENT

JAPANESE

SPINE AND SPINAL CORD DIVISION

Our spine and spinal cord division has been leading spine surgery in Japan, and has developed various novel and original surgical procedures such as expansive open-door laminoplasty (ELAP) and percutaneous nuculeotomy (PN). More than 600 spine and spinal cord surgeries are performed annually by 7 spine surgeons. Also, we have great efforts on basic and clinical researches, such as spinal cord regeneration, identification of genetic factors in inter vertebral disc and scoliosis, spinal cord and nerve root imaging, and development of novel treatment in spinal disorders.

STAFF

Ken Ishii MD, PhD

Assistant Professor
Graduate Year 1993
SpecialtyDegenerative disease in spine, Minimum invasive surgery for spine, Spine & Spinal cord surgery, Basic research for infection
Study in AbroadGeorgetown University (USA)
Harvard University (USA)

Takeshi Miyamoto, MD

Assistant professor
Graduate Year 1995
SpecialtyBone and mineral metabolism, osteoporosis

Kota Watanabe MD, PhD

Assistant Professor
Graduate Year 1997
SpecialtySpine surgery, Spinal deformity, Endoscopic spinal surgery, Scoliosis
Study in AbroadWashington University (USA)

Mitsuru Yagi, MD

Instructor
Graduate Year 1999
SpecialtySpine surgery, Endoscopic spinal surgery, Scoliosis, Metastatic tumors of spine
Study in Abroad Hospital for Special Surgery (USA)

Nobuyuki Fujita MD, PhD

Instructor
Graduate Year2000
SpecialtySpine surgery, Spinal deformity, Basic research for inter vertebral disc,
Study in Abroad Thomas Jefferson University (USA)

Narihito Nagoshi, MD

Instructor
Graduate Year 2002
SpecialtyDegenerative disease in spine, Injury of the spine, Spinal cord regeneration
Study in Abroad Toronto University (Canada)

Osahiko Tsuji, MD

Instructor
Graduate Year2003
SpecialtySpine surgery, Spinal cord tumor, Spinal cord injury, Basic research for spinal cord regeneration

SPINAL CARD REGENERATION

PAGETOP

PROJECTS

Corrective surgeries for spinal deformity

We achieved high correction ration by corrective surgeries for spinal deformity, such as adolescent idiopathic scoliosis and adult spinal deformity. We commonly perform pedicle screw instrumentation, growing rod technique for infant scoliosis, and spinal osteotomy for adult spinal deformity. Our study to identify genetic factor of adolescent idiopathic scoliosis has been published in Nature Genetics in 2012.


Surgical treatment of Spinal cord tumor and Spinal cord imaging

In 2014, we performed surgery to more than 100 cases of spinal tumor and disorders, which is one of the leading number in Japan. We achieved successful clinical results by using spinal cord monitoring and CUSA, even with the severe cases. We corroborate with Department of Radiology to develop spinal cord imaging such as diffuse tensor tractgraphy (DTT) for spinal cord and spinal root.


Minimally Invasive spine Stabilization : MISt

We perform minimum invasive spinal surgery for metastatic tumor in spine, to care their pain and improve their ADL. Minimally Invasive spine stabilization (MISt) has many advantages in surgical bleeding, rate of infection, and post-operative rehabilitation, compared to the standard procedure

Spinous process splitting approach for lumbar canal stenosis

We developed novel approach for lumbar canal stenosis. Spinous process splitting approach has many advantages in post-operative pain, duration of bed rest, and preserving of muscle, bone and ligament of the lumbar spine.

XLIF

We perform XLIF by 3 instructed spinal surgeons since 2013. Using this technique, decompression of spinal nerve can be achieved without direct invasion to the nerve by 4cm incision in lateral abdomen. XLIF can be applied to various spinal disorders such as lumbar disc herniation, lumbar canal stenosis, lumbar listhesis and degenerative spinal deformity.

Balloon Kyphoplasty (BKP)

We perform Balloon Kyphoplasty (BKP) for pathological and osteoporotic vertebral fractures. Using this technique, reconstruction and fixation of the collapsed vertebra can be achieved by 5mm double incisions under general anesthesia.

Posterior fusion for cervical instability and deformity

We perform cervical spine instrumentation for cervical spinal diseases such as myelopathy due to cervical instability, kyphotic deformity and drop head syndrome. With this technique, we can achieve better clinical results for those diseases compared to spinal cord decompression alone.

Our contribution in treatment of spinal disease using MISt was released in‘Yomiuri’on February 2, 2015.

PAGETOP

REFERENCES (IMPACT FACTOR)

Iwanami A, Kobayashi Y, Takano M, Mikami S, Toyama Y, Nakamura M. Invasive dumbbell spinal meningiomas: report of four cases and a review of the literature. Journal of Orthopaedic Science (JOS) 20: 1148-1154, 2015

Ogura Y, Miyake N, Kou I, Iida A, Nakajima M, Takeda K, Fujibayashi S, Shiina M, Okada E, Toyama Y, Iwanami A, Ishii K, Ogata K, Asahara H, Matsumoto N, Nakamura M, Matsumoto M, Ikegawa S. Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst. PLoS ONE 10(11): 142126, 2015

Hikata T, Watanabe K, Fujita N, Iwanami A, Hosogane N, Ishii K, Nakamura M, Toyama Y, Matsumoto M. Impact of sagittal spinopelvic alignment on clinical outcomes after decompression surgery for lumbar spinal canal stenosis without coronal imbalance. Journal of Neurosurgery. Spine Oct;23(4): 451-458, 2015

Booka E, Kawakubo H, Ishii K, Hikata T, Fukuda K, Nakamura R, Takahashi T, Wada N, Ishii Y, Takeuchi H, Kitagawa Y. Superior Mesenteric Artery Syndrome Caused by Massive Lumbar Osteophytes: A Case Report. Spine Aug 1;40(1: 909-912, 2015

Yagi M, Hasegawa A, Takemitsu M, Yato Y, Machida M, Asazuma T. Incidence and the risk factors of spinal deformity in adult patient after spinal cord injury: a single center cohort study. European Spine Journal 1: 203-208, 2015

Nemani V, Kim H, Bjerke-Kroll B, Yagi M, Sacramento-Dominguez C, Akoto H, Papadopoulos E, Sanchez-Perez-Grueso F, Pellise F, Nguyen J, Wulff I, Hodes R, Boachie-Adjei O, FOCOS Spine Study Group. Preoperative halo-gravity traction for severe spinal deformities at an SRS-GOP site in West Africa: protocols, complications, and results. Spine 40: 153-161, 2015

Sato S, Yagi M, Machida M, Yasuda A, Konomi T, Miyake A, Fujiyoshi K, Kaneko S, Takemitsu M, Machida M, Yato Y, Asazuma T. Reoperation rate and risk factors of elective spinal surgery for degenerative spondylolisthesis: minimum 5-year follow-up. Spine Journal 15: 1533-1544, 2015

Hasegawa A, Yagi M, Takemitsu M, Machida M, Asazuma T, Ichimura S. Atlantoaxial Subluxation after Pyogenic Spondylitis around the Odontoid Process. Case Reports in Orthopedics, 2015

Yagi M, Hosogane N, Watanabe K, Asazuma T, Matsumoto M, Keio Spine Research Group. The paravertebral muscle and psoas for the maintenance of global spinal alignment in patient with degenerative lumbar scoliosis. Spine Journal, 2015

Sacramento-Dominguez C, Yagi M, Ayanga J, Nemani V, Akoto H, Wulff I, Gupta M, Papadopoulos E, Pellise F, Sanchez-Perez-Grueso F, Hess W, Kim H, Hodes R, Boachie-Adjei O, FOCOS Spine Research Group. Apex of deformity for three-column osteotomy. Does it matter in the occurrence of complications? Spine Journal 15: 2351-2359, 2015

Yagi M, Ssato S, Miyake A, Asazuma T. Traumatic Death due to Simultaneous Double Spine Fractures in Patient with Ankylosing Spondylitis. Case Reports in Orthopedics, 2015

Nagoshi N, Kaneko S, Fujiyoshi K, Takemitsu M, Yagi M, Iizuka S, Miyake A, Hasegawa A, Machida M, Konomi T, Machida M, Asazuma T, Nakamura M. Characteristics of neuropathic pain and its relationship with quality of life in 72 patients with spinal cord injury. Spinal Cord, 2015

Okada E, Nakamura M, Koshida Y, Mukai K, Toyama Y, Matsumoto M. Breast carcinoma metastasis to meningioma in the thoracic spine: A case report and review of the literature. Spinal Cord 38: 231-235, 2015

Eijiro O, Kota W, Long P, Yohei T, Naobumi H, Yoshiaki T, Morio M. Posterior Correction and Fusion Surgery Using Pedicle-Screw Constructs for Lenke Type 5C Adolescent Idiopathic Scoliosis. A Preliminary Report. Spine 40: 25-30, 2015

Nakashima H, Tetreault L, Nagoshi N, Nouri A, Kopjar B, Arnold P, Bartels R, Defino H, Kale S, Zhou Q, Fehlings M. Does age affect surgical outcomes in patients with degenerative cervical myelopathy? Results from the prospective multicenter AOSpine International study on 479 patients. Journal of Neurology, Neurosurgery, and psychiatry, 2015

Nakashima H, Nagoshi N, Fehlings M. Timing of Surgery in the Setting of Acute Spinal Cord Injury. Current Surgery Reports 3: 1-9, 2015

Nagoshi N, Nakashima H, Fehlings M. Riluzole as a neuroprotective drug for spinal cord injury: from bench to bedside. Molecules 20: 7775-7789, 2015

Nagoshi N, Fehlings M. Investigational drugs for the treatment of spinal cord injury: review of preclinical studies and evaluation of clinical trials from phase I to II. Expert Opinion On Investigational Drugs 24: 645-658, 2015

Fehlings M, Nakashima H, Nagoshi N, Chow D, Grossman R, Kopjar B. Design and Critical Endpoints for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): A randomized, double-blinded, placebo-controlled parallel multi-center trial. Spinal Cord, 2015

Ogawa R, Hikata T, Mikami S, Fujita N, Iwanami A, Watanabe K, Ishii K, Nakamura M, Toyama Y, Matsumoto M. Total en bloc spondylectomy for locally aggressive vertebral hemangioma causing neurological deficits. Case Reports in Orthopedics :724364, 2015

Watanabe K, Fujita N, Iwanami A, Hosogane N, Ishii K, Nakamura M, Toyama Y, Matsumoto M. Impact of sagittal spinopelvic alignment on clinical outcomes after decompression surgery for lumbar spinal canal stenosis without coronal imbalance. Journal of Neurosurgery. Spine 4: 451-458, 2015

Zhang L, Kaneko S, Kikuchi K, Sano A, Maeda M, Kishino A, Shibata S, Mukaino M, Toyama Y, Liu M, Kimura T, Okano H1, Nakamura M. Rewiring of regenerated axons by combining treadmill training with semaphorin 3A inhibition. Molecular Brain 7: 14,2014

Funao H, Ishii K, Momoshima S, Iwanami A, Hosogane N, Watanabe K, Nakamura M, Toyama T, Matsumoto M. Surgeons' exposure to radiation in single- and multi-level minimally invasive transforaminal lumbar interbody fusion; A prospective study. PLoS One 9: e95233, 2014. (3.534)

Matsumoto M, Watanabe K, Kawakami N, Tsuji T, Uno K, Suzuki T, Ito M, Yanagida H, Minami S, Akazawa T. Postoperative shoulder imbalance in Lenke Type 1A adolescent idiopathic scoliosis and related factors. BMC Musculoskeletal Disorders 15: 366, 2014. (1.898)

Pang L, Watanabe K, Toyama Y, Matsumoto M. Massive hemothorax caused by Gelpi retractor during posterior correction surgery for adolescent idiopathic scoliosis: a case report. Scoliosis 9: e17, 2014. (1.31)

Fukuda K, Takemitsu M, Machida M, Asazuma T. Lumbosacral fixation using sacroiliac buttress screws: A modification to the Jackson technique with intrasacral rods. Scoliosis 9: e17, 2014

Kobayashi Y, Iwanami A, Tsuji O, Takano M, Kimura T, Toyama Y, Nakamura M. Extramedullary non-myxopapillary ependymoma of the cauda equina; a case report and review of the literature. Journal of Spine & Neurosurgery 4: 2, 2014. (in press)

Nagoshi N, Suda K, Morita T, Matsumoto S, Iimoto S, Yasui K, Komatsu M, Kobayashi Y, Minami A, Toyama Y, Matsumoto M, Nakamura M. C1 posterior arch screw as an auxiliary anchor in posterior reconstruction for atlantoaxial dislocation associated with type II odontoid fracture: a case report and review of the literature. Springerplus. 3: 672, 2014. (in press)

Matsukawa K, Yato Y, Hynes RA, Imabayashi H, Hosogane N, Asazuma T, Toshiyasu M, Kobayashi Y, Nemoto K. Cortical bone trajectory for thoracic pedicle screws. Journal of Spinal Disorders & Techniques 26: e248-e253, 2014

Qin Y, Fu M, Takahashi M, Iwanami A, Kuga D, Rao RG, Sudhakar D, Huang T, Kiyohara M, Torres K, Dillard C, Inagaki A, Kasahara N, Goodglick L, Braun J, Mischel PS, Gordon LK, Wadehra M. Epithelial membrane protein-2 (EMP2) activates src and is a novel therapeutic target for glioblastoma. Journal of Biological Chemistry 289: 13974-13985, 2014

Nemoto O, Asazuma T, Yato Y, Imabayashi H, Yasuoka H, Fujikawa A. Comparison of fusion rates following transforaminal lumbar interbody fusion using polyetheretherketone cages or titanium cages with transpedicular instrumentation. European Spine Journal 23: 2150-2155, 2014

Satoh S, Yagi M, Machida M, Yasuda A, Konomi T, Miyake A, Fujiyoshi K, Kaneko S, Takemitsu M, Machida M, Yato Y, Asazuma T. Reoperation rate and risk factors of elective spinal surgery for degenerative spondylolisthesis ―Minimum 5 year follow-up―. Spine Journal 15: 1536-1544, 2014

Fujii T, Watanabe K, Toyama Y, Matsumoto M. Pulmonary function recovery demonstrated by ventilation-perfusion scan after posterior vertebral column resection for severe adolescent idiopathic scoliosis: a case report. Spine. 39: 1190-1194, 2014.(2.447)

Yoshimura N, Nagata K, Mukai D, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T. Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population; A 3-year follow-up of the ROAD study. Osteoporosis International 25: 1089-1098, 2014

Nakajima M, Takahashi A, Tsuji T, Karasugi T, Baba H, Uchida K, Kawabata S, Okawa A, Shindo S, Takeuchi K, Taniguchi Y, Maeda S, Kashii M, Seichi A, Nakajima H, Kawaguchi Y, Fujibayashi S, Takahata M, Tanaka T, Watanabe K, Kida K, Kanchiku T, Ito Z, Mori K, Kaito T, Kobayashi S, Yamada K, Takahashi M, Chiba K, Matsumoto M, Furukawa K, Kubo M, Toyama Y, Ikegawa S. A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine. Nature Genetics 46: 1012-1016, 2014. (29.648)

Wu Z, Iwanami A, Yasuda A, Mikami S, Toyama Y, Nakamura M. Intramedullary cervicothoracic subependymoma: report of three cases and review of the literature. Journal of Orthopaedic Science. 20: 927-934, 2014. (in press) (1.008)

Cao K, Watanabe K, Hosogane N, Toyama Y, Yonezawa I, Machida M, Yagi M, Kaneko S, Kawakami N, Tsuji T, Matsumoto M. Association of postoperative shoulder balance with adding-on in Lenke typeⅡ adolescent idiopathic scoliosis. Spine 39: 705-712, 2014

Nakamura M, Nishiwaki Y, Sumitani M, Ushida T, Yamashita T, Konno S, Taguchi T, Toyama Y. Investigation of chronic musculoskeletal pain(third report); With special reference to the importance of neuropathic pain and psychogenic pain. Journal of Orthopaedic Science 19: 667-675, 2014

Yagi M, Patel R, Lawhorne TW, Cunningham ME, Boachie-Adjei O. Adult thoracolumbar and lumbar scoliosis treated with long vertebral fusion to the sacropelvis: A comparison between new hybrid selective spinal fusion versus anterior-posterior spinal instrumentation. Spine Journal 14: 637-645, 2014

Yagi M, Rahm M, Gaines R, Maziad A, Ross T, Kim HJ, Kebaish K, Boachie-Adjei O. Characterization and surgical outcomes of proximal junctional failure in surgically treated patients with adult spinal deformity. Spine 39: 607-614, 2014

Kawaguchi Y, Matsumoto M, Iwasaki M, Izumi T, Okawa A, Matsunaga S, Chiba K, Tsuji T, Yamazaki M, Fujimori T, Yoshii T, Toyama Y. New classification system for ossification of the posterior longitudinal ligament using CT images. Journal of Orthopaedic Science. 19: 530-536, 2014. (1.008)

Yagi M, Hosogane N, Okada E, Watanabe K, Machida M, Tezuka M, Matsumoto M, Asazuma T. Factors affecting the postoperative progression of thoracic kyphosis in surgically treated adult patients with lumbar degenerative scoliosis. Spine 39: 521-528, 2014

Ishii K, Kaneko Y, Funao H, Ishihara S, Shinohara A, Nakanishi K, Hikata T, Fujita N, Iwanami A, Hosogane N, Watanabe K, Nagura T, Nakamura M, Toyama Y, Matsumoto M. A novel percutaneous guide wire (S-Wire) for pedicle screw insertion: Its development, efficacy, and safety. Surgical Innovation 22: 469-473, 2014

Nagoshi N, Iwanami A, Toyama Y, Nakamura M. Factors contributing to improvement of syringomyelia after foramen magnum decompression for Chiari type I malformation. Journal of Orthopaedic Science 19: 418-423, 2014. (1.008)

Nakamura Y, Nojiri K, Yoshihara H, Takahata T, Honda-Takahashi K, Kubo S, Sakatsume K, Kato H, Maruta T, Honda T. Significant differences of brain blood flow in patients with chronic low back pain and acute low back pain detected by brain SPECT. Journal Orthopaedic Science 19: 384-389, 2014

Nakamura M, Nishiwaki Y, Ushida T, Toyama Y. Prevalence and characteristics of chronic musculoskeletal pain in Japan; A second survery of people with or without chronic pain. Journal of Orthopaedic Science 19: 339-350, 2014

Boachie-Adjei O, Yagi M, Sacramento-Dominguez C, Akoto H, Cunningham ME, Gupta M, Hess WF, Lonner BS, Ayamga J, Papadopoulus E, Sanchez-Perez-Grueso F, Pelise F, Paonessa KJ, Kim HJ. Surgical risk stratification based on preoperative risk factors in severe pediatric spinal deformity surgery. Spine Deformity 2: 340-349, 2014

Cao K, Watanabe K, Kawakami N, Tsuji T, Hosogane N, Yonezawa I, Machida M, Yagi M, Kaneko S, Toyama Y, Matsumoto M. Selection of lower instrumented vertebra in treating Lenke type 2A adolescent idiopathic scoliosis. Spine 39: 253-261, 2014. (2.447)

Matsukawa K, Yato Y, Kato T, Imabayashi H, Asazuma T , Nemoto K. In vivo analysis of insertional torque during pedicle screwing using cortical bone trajectory technique. Spine 39: 240-245, 2014

Hikata T, Iwanami A, Hosogane N, Watanabe K, Ishii K, Nakamura M, Kamata M, Toyama Y, Matsumoto M. High preoperative hemoglobin A1c is a risk factor for surgical site infection after posterior thoracic and lumbar spinal instrumentation surgery. Journal of Orthopaedic Science 19: 223-228, 2014. (1.008)

Yagi M, Takeda K, Machida M, Asazuma T. Discordance of gravity line and C7PL in patient with adult spinal deformity-factors affecting the occiput-trunk suggittal discordance. Spine Journal 15: 213-221, 2014

Yagi M, Hasegawa A, Takemitsu M, Yato Y, Machida M, Asazuma T. Incidence and the risk factors of spinal deformity in adult patient after spinal cord injury: A single center cohort study. European Spine Journal 24: 203-208, 2014

Matsukawa K, Yato Y, Kato T, Imabayashi H, Asazuma T, Nemoto K. Cortical bone trajectory for lumbosacral fixation: Penetrating S-1 endplate screw technique. Journal of Neurosurgery Spine 21: 203-208, 2014

Iida T, Nakamura M, Tsuji O, Iwanami A, Mikami S, Toyama Y, Chiba K, Matsumoto M. Dumbbell mesenchymal chondrosarcoma: report of a rare case. Journal of Orthopaedic Science 19: 190-193, 2014

Nemani VM, Kim HJ, Bjerke-Kroll BT, Yagi M, Sacramento-Dominguez C, Akoto H, Papadopoulos EC, Sanchez-Perez-Grueso F, Pellise F, Nguyen JT, Wulff I, Ayamga J, Mahmud R, Hodes RM, Boachie-Adjei O. Preoperative halo-gravity traction for severe spinal deformities at An SRS-GOP site in West Africa: Protocols, complications, and results. Spine 40: 153-161, 2014

Yagi M, Iizuka S, Hasegawa A, Nagoshi N, Fujiyoshi K, Kaneko S, Takemitsu M, Shioda M, Machida M. Sagittal cervical alignment in adolescent idiopathic scoliosis. Spine Deformity 2: 122-130, 2014

Hikata T, Kamata M, Furukawa M. Risk factors for adjacent segment disease after posterior lumbar interbody fusion and efficacy of simultaneous decompression surgery for symptomatic adjacent segment disease. Journal of Spinal Disorders & Techniques 27: 70-75, 2014

Shinozaki M, Nakamura M, Konomi T, Kobayashi Y, Takano M, Saito N, Toyama Y, Okano H. Distinct roles of endogenous vascular endothelial factor receptor 1 and 2 in neural protection after spinal cord injury. Neuroscience Research 78: 55-64, 2014. (2.145)

Boachie-Adjei O, Yagi M, Nemani VM, Sacramento-Dominguez C, Akoto H, Cunningham ME, Gupta M, Hess WF, Lonner BS, Mendelow MJ, Papadopoulus EC, Sanchez-Perez-Grueso F, Pelise F, Paonesa K, Wright B, Wulff I, Kim HJ. Incidence and risk factors for major surgical complications in patients with complex spinal deformity: A report from an SRS GOP site. Spine Deformity 3: 57-64, 2014

Tanaka N, Konno S, Takeshita K, Fukui M, Takahashi K, Chiba K, Miyamoto M, Matsumoto M, Kasai Y, Kanamori M, Matsunaga S, Hosono N, Kanchiku T, Taneichi H, Hashizume H, Kanayama M, Shimizu T, Kawakami M. An outcome measure for patients with cervical myelopathy: the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): An average score of healthy volunteers. Journal of Orthopaedic Science 19: 33-48, 2014

Ishikawa M, Cao K, Pang L, Watanabe K, Yagi M, Hosogane N, Machida M, Shiono Y, Nishiyama M, Fukui Y, Matsumoto M. Postoperative behavior of thoracolumbar/lumbar curve and coronal balance after posterior thoracic fusion for Lenke 1C and 2C adolescent idiopathic scoliosis. Journal of Orthopaedic Science. 20: 31-37, 2014.(1.008)

Nagoshi N, Fehlings MG. Spinal cord concussion: Pathology and recommendation for return to play. Current Research: Concussion 1: 31-32, 2014

Theologis A, Tabaraee E, Funao H, Smith J, Burch S, Tay B, Kebaish K, Deviren V, Ames C. Three-column osteotomies of the lower cervical and upper thoracic spine: comparison of early outcomes, radiographic parameters, and peri-operative complications in 48 patients. European Spine Journal 24 Suppl 1: S23-30, 2014

Shirasawa H, Ishii K, Iwanami A, Mikami S, Toyama Y, Matsumoto M, Nakamura M. Pediatric myxopapillary ependymoma treated with subtotal resection and radiation therapy: A case report and review of the literature. Spinal Cord. 52: 18-20, 2014. (1.699)

Matsumoto M, Watanabe K, Hosogane N, Toyama Y. Updates on surgical treatments for pediatric scoliosis. Journal of Orthopaedic Science 19: 6-14, 2014

Kiriyama Y, Watanabe K, Matsumoto M, Toyama Y, Nagura T. Quantification of the spatial strain distribution of scoliosis using a thin-plate spline method. Journal of Biomechanics 47: 302-307, 2014. (2.496)

Tanaka N, Konno S, Takeshita K, Fukui M, Takahashi K, Chiba K, Miyamoto M, Matsumoto M, Kasai Y, Kanamori M, Matsunaga S, Hosono N, Kanchiku T, Taneichi H, Hashizume H, Kanayama M, Shimizu T, Kawakami M. An outcome measure for patients with cervical myelopathy: Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): An average score of healthy volunteers. J Orthop Sci 19: 33-48, 2014. (1.008)

Mori T, Sato Y, Miyamoto L, Kobayashi T, Shimizu T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Iwasaki T, Kawana H, Morioka H, Matsumoto M, Saya H, Toyama Y, Miyamoto T. TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state. Oncogene 33: 4236-4241, 2014. (8.559)

Kanagawa H, Niki Y, Kobayashi T, Sato Y, Katsuyama E, Fujie A, Hao W, Miyamoto K, Tando T, Watanabe R, Morita M, Morioka H, Matsumoto M, Toyama Y, Miyamoto T. Mycobacterium tuberculosis promotes arthritis development through toll-like receptor 2. Journal of Bone and Mineral Metabolism. [Epub ahead of print] (2.114)

Yagi M, Hosogane N, Okada E, Watanabe K, Machida M, Tezuka M, Matsumoto M, Asazuma T. Factors affecting the post operative progression of thoracic kyphosis in surgically treated adult patient with lumbar degenerative scoliosis. Spine 39: E521-528, 2014. (2.447)

Londono D, Kou I, Johnson TA, Sharma S, Ogura Y, Tsunoda T, Takahashi A, Matsumoto M, Herring JA, Lam TP, Wang X, Tam EMS, Song YQ, Fan YH, Chan D, Cheah KSE, Qiu X, Jiang H, Huang D, Japanese Scoliosis Clinical Research Group, TSRHC IS Clinical Group, the International Consortium for Scoliosis Genetics, Su P, Sham P, Cheung KMC, Luk KDK, Gordon1 D, Qiu Y, Cheng J, Tang N, Ikegawa S, Wise CA. A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. Journal of Medical Genetics 51: 401-406, 2014. (5.636)

Kakinuma H, Ishii K, Ishihama H, Honda M, Toyama Y, Matsumoto M, Aizawa M. Anti-bacterial polyetheretherketone implants immobilized with silver ions based on chelate-bonding ability of inositol phosphate: Processing, material characterization, cytotoxicity and anti-bacterial properties.Journal of Biomedical Materials Research Part A, 2014. [Epub ahead of print] ( 2.841)

Oh JK, Smith JS, Shaffrey CI, Lafage V, Schwab F, Ames CP, Matsumoto M, Baik JS, Ha Y. Sagittal spino-pelvic malalignment in Parkinson's disease: prevalence and associations with disease severity. Spine 39: E833-841, 2014. (2.447)

Cao K, Watanabe K, Hosogane N, Toyama Y, Yonezawa I, Machida M, Yagi M, Kaneko S, Kawakami N, Tsuji T, Matsumoto M. Association of postoperative shoulder balance with adding-on in Lenke type II adolescent idiopathic scoliosis. Spine 39: E705-712, 2014. (2.447)

Watanabe K, Uno K, Suzuki T, Kawakami N, Tsuji T, Yanagida H, Ito M, Hirano T, Yamazaki K, Minami S, Taneichi H, Imagama S, Takeshita K, Yamamoto T, Matsumoto M. Risk factors for proximal junctional kyphosis associated with dual-rod growing-rod surgery for early-onset scoliosis. Journal of Spinal Disorders and Techniques 2014. [Epub ahead of print] (1.888)

Matsumoto M, Hikata T, Iwanami A, Hosogane N, Watanabe K, Ishii K, Nakamura M, Toyama Y. Major complications and sequelae after total en bloc spondylectomy for malignant spinal tumors. Neurosurgery Quarterly. (in press) (0.089)

Choi HJ, Smith JS, Shaffrey CI, Lafage V, Schwab F, Ames CP, Matsumoto M, Baik JS, Ha Y. Coronal Plane Spinal Malalignment and Parkinson's Disease: Prevalence and Associations with Disease Severity. Spine Journal 2014. [Epub ahead of print] (2.8)

Nakayama R, Horiuchi K, Susa M, Watanabe I, Watanabe K, Tsuji T, Matsumoto M, Toyama Y, Morioka H. Clinical Outcome after Bone Metastasis (BM) Surgery in Patients with Differentiated Thyroid Carcinoma (DTC): A Retrospective Study of 40 Cases. Japanese Journal of Clinical Oncology. 2014. [Epub ahead of print] (1.747)

Yoshioka K, Ishii K, Kuramoto T, Nagai S, Funao H, Ishihama H, Shiono Y, Sasaki A, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M. A novel mouse model of soft-tissue infection using bioluminescence imaging allows noninvasive, real-time monitoring of bacterial growth. PLoS One 9: e106367, 2014. (3.534)

Sato Y, Miyauchi Y, Yoshida S, Morita M, Kobayashi T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Watanabe R, Miyamoto K, Morioka H, Matsumoto M, Toyama Y, Miyamoto T. The Vitamin D Analogue ED71 but Not 1, 25 (OH) 2D3 Targets HIF1α Protein in Osteoclasts. PLoS One: 9: e111845, 2014. (3.534)

Katsuyama E, Miyamoto H, Kobayashi T, Sato Y, Hao W, Kanagawa H, Fujie A, Tando T, Watanabe R, Morita M, Miyamoto K, Niki Y, Morioka H, Matsumoto M, Toyama Y, Miyamoto T. Interleukin-1 receptor-associated kinase-4 (IRAK4) promotes inflammatory osteolysis by activating osteoclasts and inhibiting formation of foreign body giant cells. Journal of Biological Chemistry 2014. [Epub ahead of print] (4.600)

Ishii K, Kaneko Y, Funao H, Ishihara S, Shinohara A, Nakanishi K, Hikata T, Fujita N, Iwanami A, Hosogane N, Watanabe K, Nagura T, Nakamura M, Toyama Y, Matsumoto M. A novel percutaneous guide wire (S-Wire) for percutaneous P pedicle screw insertion: Its development, efficacy, and safety. Surgical Innovation 2014. [Epub ahead of print] (1.338)

Okada E, Watanabe K, Pang L, Ogura Y, Takahashi Y, Hosogane N, Toyama Y, Matsumoto M: Posterior correction and fusion surgery using pedicle-screw constructs for Lenke type 5C adolescent idiopathic scoliosis. A preliminary report. Spine. (in press) (2.447)

Uchikawa S, Yoda M, Tohmonda T, Kanaji A, Matsumoto M, Toyama Y, Horiuchi K. ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface. Cytokine 71: 238-245, 2014. (2.874)

Okada E, Nakamura M, Koshida Y, Mukai K, Toyama Y, Matsumoto M. Breast carcinoma metastasis to meningioma in the thoracic spine: a case report and review of the literature. Journal of Spinal Cord Medicine (in press) (1.878)

Takano M, Kawabata S, Komaki Y, Shibata S, Hikishima K, Toyama Y, Okano H, Nakamura M. Inflammatory cascades mediate synapse elimination in spinal cord compression. J Neuro inflammation 11: 40, 2014. (4.902)

Zhang L, Kaneko S, Kikuchi K, Sano A, Maeda M, Kishino A, Shibata S, Mukaino M, Toyama Y, Liu M, Kimura T, Okano H, Nakamura M. Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition. Mol Brain 7: 14, 2014. (4.35)

Nakamura M, Nishiwaki Y, Ushida T, Toyama Y. Prevalence and chracteristics of chronic muscloskeletal pain in Japan: A second survery of people with or without chronic pain. J Orthop Sci 19: 339-350, 2014. (1.008)

Sumitani M, Yasunaga H, Uchida K, Horiguchi H, Nakamura M, Ohe K, Fushima K, Matsuda S, Yamada Y. Perioperative factors affecting the occurrence of acute complex regional pain syndrome following limb bone fracture surgery: Data from the Japanese Diagnosis Procedure Combination database. Rheumatology 53: 1186-1193, 2014. (4.435)

Nakamura M, Nishiwaki Y, Ushida T, Toyama Y. Prevalence and characteristics of chronic musculoskeletal pain in Japan: a second survey of people with or without chronic pain. J Orthop Sci 19: 339-350, 2014. (1.008)

Nakamura M, Nishiwaki Y, Sumitani M, Ushida T, Yamashita T, Konno S, Taguchi T, Toyama Y. Investigation of chronic musculoskeletal pain (third report): with special reference to the importance of neuropathic pain and psychogenic pain. J Orthop Sci 19: 667-675, 2014. (1.008)

Nishimura S, Sasaki T, Shimizu A, Yoshida K, Iwai H, Koya I, Kobayashi Y, Itakura G, Shibata S, Ebise H, Horiuchi K, Kudoh J, Toyama Y, Anderson AJ, Okano H, Nakamura M. Global gene expression analysis following spinal cord injury in non-human primates. Exp Neurol 261: 171-179, 2014. (4.617)

Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue. Focal transplantation of human iPSC-derived glial-rich neural progenitors improveslifespan of ALS mice.Stem Cell Reports 12: 242-249, 2014.

Sumitani M, Kogure T, Nakamura M, Shibata M, Yozu A, Otake Y, Yamada Y. Classification of the pain nature of CRPS type 1, based on patient complaints, into neuropathic pain and nociceptive/inflammatory pain, using the McGill Pain Questionnaire. J Anesthesia. (in press) (1.117)

Iwai H, Nori S, Nishimura S, Yasuda A, Takano O, Fujiyoshi K, Toyama Y, Okano H, Nakamura M. Transplantation of neural stem/progenitor cells at different locations in mice with spinal cord injury. Cell Transplant. (in press) (3.57)

Tashiro S, Shinozaki M, Mukaino M, Renault-Mihara F, Toyama Y, Liu M, Nakamura M, Okano H. BDNF Induced by Treadmill Training Contributes to the Suppression of Spasticity and Allodynia After Spinal Cord Injury via Upregulationof KCC2. Neurorehabil Neural Repair 2014. (in press) (4.617)

Itakura G, Kobayashi Y, Nishimura S, Iwai H, Takano M, Iwanami A, Toyama Y, Okano H, Nakamura M. Control of the survival and growth of human glioblastoma grafted into the spinal cord of mice by taking advantage of immunorejection. Cell transplantation. (in press) (3.57)

Nakamura M, Ushida T, Toyama Y. Reply to letter to the editor by Toda. J Orthop Sci 2014. (in press) (1.008)

Nishikawa R, Hotta R, Shimojima N, Shibata S, Nagoshi N, Nakamura M, Matsuzaki Y, Okano HJ, Kuroda T, Okano H, Morikawa Y. Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung's disease. Cytotechnology 2014. (in press) (1.449)

Iwanami A, Kobayashi Y, Takano M, Mikami S, Toyama Y, Nakamura M. Invasive dumbbell spinal meningiomas: report of four cases and a review of the literature. J Orthop Sci 2014. (in press) (1.008)

Itakura G, Kobayashi Y, Nishimura S, Iwai H, Takano M, Iwanami A, Toyama Y, Okano H, Nakamura M. Controlling immune rejection is a fail-safe system against potential tumorigenicity after human iPSC-derived neural stem cell transplantation. PLoS One 2014. (in press) (3.534)

Nori S, Okada Y, Nishimura S, Sasaki T, Itakura G, Kobayashi Y, Renault-Mihara F, Shimizu A, Koya I, Yoshida R, Kudoh J, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Nakamura M, Okano H. Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition. Stem Cell Reports 2014. (in press)

Matsui T, Akamatsu W, Nakamura M, Okano H. Regeneration of the damaged central nervous system through reprogramming technology: basic concepts and potential application for cell replacement therapy. Exp Neurol 260: 12-18, 2014. (4.617)

Qin Y, Fu M, Takahashi M, Iwanami A, Kuga D, Rao RG, Sudhakar D, Huang T, Kiyohara M, Torres K, Dillard C, Inagaki A, Kasahara N, Goodglick L, Braun J, Mischel PS, Gordon LK, Wadehra M. Epithelial membrane protein-2 (emp2) activates src and is a novel therapeutic target for gbm. The Journal of biological chemistry. 2014. (in press) (4.600)

Fujita N, Hirose Y, Tran CM, Chiba K, Miyamoto T, Toyama Y, Shapiro IM, Risbud MV. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. FASEB J. 6: 2455-65, 2014. (5.480)

Nishimon M, Shimizu Y, Ueno M, Iwanami A. Late-onset congenital lateral dermal sinus tract. BMJ Case Rep. 2014. (in press)

Iwanami A, Toyama Y. Cervical spondylosis. Nihon rinsho. Japanese journal of clinical medicine 72: 1755-1760, 2014.

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