整形外科学教室

  • ごあいさつ
  • 組織
  • 脊椎・脊髄グループ
  • 上肢グループ
  • 下肢グループ
  • 骨・軟部腫瘍グループ
  • スポーツグループ
  • 基礎研究グループ
  • 実績
  • 沿革
  • 学生教育・大学院
  • 留学
  • 医局風景・イベント
  • 関連リンク・関連学会
  • 学会・研究会
  • 臨床研究

ENGLISH

脊椎・脊髄グループ

概要

慶應義塾大学の脊椎・脊髄診療班は日本のパイオニアとして、片開き式頚部脊柱管拡大術(ELAP)、経皮的髄核摘出術(PN)などオリジナリティーが高く、世界に広く用いられている手術術式を考案し、この分野で指導的役割を果たしてきました。現在7名の専門医(脊椎内視鏡下手術・技術認定医2名)を擁し、年間手術件数は500件を超えています。また当班では脊髄再生、椎間板や側弯症の原因遺伝子同定、椎間板の加齢変化に関するMRIや軟骨代謝マーカーを用いた研究、新しい医療用デバイスの開発など、さまざまな基礎的および臨床的研究を行っております。

スタッフ紹介

渡辺 航太 Kota Watanabe

講師
卒業年度1997年
専門脊椎一般、脊柱変形、腰椎内視鏡下手術、側弯症
留学2005年 - 2006年 ワシントン大学(アメリカ)

八木 満 Mitsuru Yagi

講師
卒業年度 1999年
専門脊椎一般、脊椎内視鏡下手術、成人側弯症、小児側弯症、転移性脊椎腫瘍
留学 2009年 - 2010年 ホスピタル フォア スペシャル サージェリー (ニューヨーク、アメリカ)

藤田 順之 Nobuyuki Fujita

講師
卒業年度2000年
専門脊椎一般、椎間板代謝、骨軟骨代謝、脊柱変形
留学 2010年 - 2012年 トーマスジェファーソン大学
(アメリカ)

岡田 英次朗 Eijiro Okada

助教
卒業年度2001年
専門脊椎一般、低侵襲脊椎手術、脊柱変形
留学 2010年 - 2011年 カリフォルニア大学サンフランシスコ校
(アメリカ)

名越 慈人 Narihito Nagoshi

助教
卒業年度 2002年
専門脊椎変性疾患、脊椎外傷、脊髄再生
留学 2014年 - 2015年 トロント大学(カナダ)

辻 収彦 Osahiko Tsuji

助教
卒業年度2003年
専門脊椎脊髄一般、脊髄腫瘍、脊髄損傷、脊髄再生

宮本 健史 Takeshi Miyamoto

特任准教授
卒業年度1995年
専門骨代謝、骨粗鬆症

脊髄再生のページはこちら

慶應義塾大学病院 整形外科 外来表はこちら

PAGETOP

実績紹介

脊柱変形に対する矯正手術

特発性側彎症をはじめとする、脊柱変形に対しPedicle Screwを使用したinstrumentationにより高い矯正率を達成しています。成長期幼児側彎に対する Growing Rod法、成人側彎に対する骨切り術の併用なども積極的に行っています。また2012年には側彎症の原因遺伝子に関する研究がNature Geneticsに掲載されました。


脊髄腫瘍に対する外科的治療・脊髄イメージング

脊髄に発生する髄外・髄内腫瘍に対し、日本でも有数の手術件数を行っています。術中モニタリングやCUSAの併用により、難易度の高い症例でも良好な成績を得ています。
また放射線診断部と共同で、脊髄・神経根に対する拡散テンソル投射路撮影(DTT)による脊髄イメージングにも取り組んでいます。


ミスト(Minimally Invasive spine Stabilization : MISt)最小侵襲脊椎安定術

転移性脊椎腫瘍による麻痺や痛みで苦しんでいる患者さんの苦痛を少しでも軽減するために低侵襲脊椎手術を行っています。従来の切開手術に比べ、術中・術後の出血量が少ないことが証明されております。身体に対する負担が少ないために術後早期リハビリが可能です。

腰部脊柱管狭窄症に対する棘突起縦割アプローチ

社会の高齢化に伴い脊柱管狭窄症が増加しています。本症に対するスタンダードな手術である椎弓切除術において、術後の疼痛軽減、安静期間の短縮、腰背部の筋肉、靭帯、骨など正常組織の温存を目的とした腰椎棘突起縦割式椎弓切除術を考案しました。

XLIF(エックスリフ)

MIS-TLIFやミストと同様に日本で普及しつつある低侵襲手術で、欧米では約10年前、日本では2013年から承認され実施されています。特にXLIF(エックスリフ)は全国でも限られた医師と医療機関でのみ実施されており、当院では現在3名の医師が実施許可を取得し、すでに数多くの実績があります。また、病態によりOLIF(オーリフ)と呼ばれる類似の手技も導入しています。
手術では側腹部に約4cmの傷で手術を実施します。この手技の最大の利点は神経を直接触らないで神経を圧迫から解除する事にあります。側腹部に約4cmの傷から、右下の図のように神経機能を随時確認し重要な神経を避けながら椎間板内に人工骨を移植します。その後、腰部から固定術を行います。対象となる疾患は、腰椎椎間板ヘルニア、腰部脊柱管狭窄(症)、腰椎変性すべり症、腰椎変性側弯症(成人脊柱変形)、腰椎後弯症、腰椎分離(すべり)症の一部などです。原則、手術翌日より起立・歩行を開始します。入院期間は最短で約7日程度ですが、病態により異なります。また手術後は硬いコルセットを装着します。

経皮的椎体形成術(Balloon Kyphoplasty:BKP)

脊椎圧迫骨折や転移性脊椎腫瘍による病的骨折に対して世界中で行われている低侵襲経皮的椎体形成術(Percutaneous Vertebroplasty:PVP)の1手術法です。全身麻酔下に背中の約5mmの傷2ヶ所から細い針を骨折椎体に挿入します。その針を介して風船(Balloon)を骨折椎体内に設置し、ゆっくりと潰れた骨を整復・復元します。整復後に除去した風船のスペースにPMMAセメント(人工骨)を注入して、骨折を人工的に接合します。原則、手術翌日より起立・歩行を開始します。入院期間は最短で約7日程度ですが、病態により異なります。また手術後は軟らかいコルセットを装着します。

頚椎後方除圧固定術

不安定性(頚椎のぐらつき)を伴う頚髄症・後弯変形を合併した後縦靭帯骨化症・首下がり病といわれる重度の頚椎後弯症に対しては、脊髄の圧迫をとるために骨を削る手術だけを行うと、術後の変形が進行したり、麻痺の症状が改善しないことがあります。そこで我々は、神経モニタリングを使用した上で安全に脊髄の除圧を行った後に、金属を使用して頚椎の変形を矯正し安定化させる手術を行っております。

PAGETOP

業績(カッコ内はインパクトファクター)

Iwanami A, Kobayashi Y, Takano M, Mikami S, Toyama Y, Nakamura M. Invasive dumbbell spinal meningiomas: report of four cases and a review of the literature. Journal of Orthopaedic Science (JOS) 20: 1148-1154, 2015

Ogura Y, Miyake N, Kou I, Iida A, Nakajima M, Takeda K, Fujibayashi S, Shiina M, Okada E, Toyama Y, Iwanami A, Ishii K, Ogata K, Asahara H, Matsumoto N, Nakamura M, Matsumoto M, Ikegawa S. Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst. PLoS ONE 10(11): 142126, 2015

Hikata T, Watanabe K, Fujita N, Iwanami A, Hosogane N, Ishii K, Nakamura M, Toyama Y, Matsumoto M. Impact of sagittal spinopelvic alignment on clinical outcomes after decompression surgery for lumbar spinal canal stenosis without coronal imbalance. Journal of Neurosurgery. Spine Oct;23(4): 451-458, 2015

Booka E, Kawakubo H, Ishii K, Hikata T, Fukuda K, Nakamura R, Takahashi T, Wada N, Ishii Y, Takeuchi H, Kitagawa Y. Superior Mesenteric Artery Syndrome Caused by Massive Lumbar Osteophytes: A Case Report. Spine Aug 1;40(1: 909-912, 2015

Yagi M, Hasegawa A, Takemitsu M, Yato Y, Machida M, Asazuma T. Incidence and the risk factors of spinal deformity in adult patient after spinal cord injury: a single center cohort study. European Spine Journal 1: 203-208, 2015

Nemani V, Kim H, Bjerke-Kroll B, Yagi M, Sacramento-Dominguez C, Akoto H, Papadopoulos E, Sanchez-Perez-Grueso F, Pellise F, Nguyen J, Wulff I, Hodes R, Boachie-Adjei O, FOCOS Spine Study Group. Preoperative halo-gravity traction for severe spinal deformities at an SRS-GOP site in West Africa: protocols, complications, and results. Spine 40: 153-161, 2015

Sato S, Yagi M, Machida M, Yasuda A, Konomi T, Miyake A, Fujiyoshi K, Kaneko S, Takemitsu M, Machida M, Yato Y, Asazuma T. Reoperation rate and risk factors of elective spinal surgery for degenerative spondylolisthesis: minimum 5-year follow-up. Spine Journal 15: 1533-1544, 2015

Hasegawa A, Yagi M, Takemitsu M, Machida M, Asazuma T, Ichimura S. Atlantoaxial Subluxation after Pyogenic Spondylitis around the Odontoid Process. Case Reports in Orthopedics, 2015

Yagi M, Hosogane N, Watanabe K, Asazuma T, Matsumoto M, Keio Spine Research Group. The paravertebral muscle and psoas for the maintenance of global spinal alignment in patient with degenerative lumbar scoliosis. Spine Journal, 2015

Sacramento-Dominguez C, Yagi M, Ayanga J, Nemani V, Akoto H, Wulff I, Gupta M, Papadopoulos E, Pellise F, Sanchez-Perez-Grueso F, Hess W, Kim H, Hodes R, Boachie-Adjei O, FOCOS Spine Research Group. Apex of deformity for three-column osteotomy. Does it matter in the occurrence of complications? Spine Journal 15: 2351-2359, 2015

Yagi M, Ssato S, Miyake A, Asazuma T. Traumatic Death due to Simultaneous Double Spine Fractures in Patient with Ankylosing Spondylitis. Case Reports in Orthopedics, 2015

Nagoshi N, Kaneko S, Fujiyoshi K, Takemitsu M, Yagi M, Iizuka S, Miyake A, Hasegawa A, Machida M, Konomi T, Machida M, Asazuma T, Nakamura M. Characteristics of neuropathic pain and its relationship with quality of life in 72 patients with spinal cord injury. Spinal Cord, 2015

Okada E, Nakamura M, Koshida Y, Mukai K, Toyama Y, Matsumoto M. Breast carcinoma metastasis to meningioma in the thoracic spine: A case report and review of the literature. Spinal Cord 38: 231-235, 2015

Eijiro O, Kota W, Long P, Yohei T, Naobumi H, Yoshiaki T, Morio M. Posterior Correction and Fusion Surgery Using Pedicle-Screw Constructs for Lenke Type 5C Adolescent Idiopathic Scoliosis. A Preliminary Report. Spine 40: 25-30, 2015

Nakashima H, Tetreault L, Nagoshi N, Nouri A, Kopjar B, Arnold P, Bartels R, Defino H, Kale S, Zhou Q, Fehlings M. Does age affect surgical outcomes in patients with degenerative cervical myelopathy? Results from the prospective multicenter AOSpine International study on 479 patients. Journal of Neurology, Neurosurgery, and psychiatry, 2015

Nakashima H, Nagoshi N, Fehlings M. Timing of Surgery in the Setting of Acute Spinal Cord Injury. Current Surgery Reports 3: 1-9, 2015

Nagoshi N, Nakashima H, Fehlings M. Riluzole as a neuroprotective drug for spinal cord injury: from bench to bedside. Molecules 20: 7775-7789, 2015

Nagoshi N, Fehlings M. Investigational drugs for the treatment of spinal cord injury: review of preclinical studies and evaluation of clinical trials from phase I to II. Expert Opinion On Investigational Drugs 24: 645-658, 2015

Fehlings M, Nakashima H, Nagoshi N, Chow D, Grossman R, Kopjar B. Design and Critical Endpoints for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): A randomized, double-blinded, placebo-controlled parallel multi-center trial. Spinal Cord, 2015

Ogawa R, Hikata T, Mikami S, Fujita N, Iwanami A, Watanabe K, Ishii K, Nakamura M, Toyama Y, Matsumoto M. Total en bloc spondylectomy for locally aggressive vertebral hemangioma causing neurological deficits. Case Reports in Orthopedics :724364, 2015

Watanabe K, Fujita N, Iwanami A, Hosogane N, Ishii K, Nakamura M, Toyama Y, Matsumoto M. Impact of sagittal spinopelvic alignment on clinical outcomes after decompression surgery for lumbar spinal canal stenosis without coronal imbalance. Journal of Neurosurgery. Spine 4: 451-458, 2015

Zhang L, Kaneko S, Kikuchi K, Sano A, Maeda M, Kishino A, Shibata S, Mukaino M, Toyama Y, Liu M, Kimura T, Okano H1, Nakamura M. Rewiring of regenerated axons by combining treadmill training with semaphorin 3A inhibition. Molecular Brain 7: 14,2014

Funao H, Ishii K, Momoshima S, Iwanami A, Hosogane N, Watanabe K, Nakamura M, Toyama T, Matsumoto M. Surgeons' exposure to radiation in single- and multi-level minimally invasive transforaminal lumbar interbody fusion; A prospective study. PLoS One 9: e95233, 2014. (3.534)

Matsumoto M, Watanabe K, Kawakami N, Tsuji T, Uno K, Suzuki T, Ito M, Yanagida H, Minami S, Akazawa T. Postoperative shoulder imbalance in Lenke Type 1A adolescent idiopathic scoliosis and related factors. BMC Musculoskeletal Disorders 15: 366, 2014. (1.898)

Pang L, Watanabe K, Toyama Y, Matsumoto M. Massive hemothorax caused by Gelpi retractor during posterior correction surgery for adolescent idiopathic scoliosis: a case report. Scoliosis 9: e17, 2014. (1.31)

Fukuda K, Takemitsu M, Machida M, Asazuma T. Lumbosacral fixation using sacroiliac buttress screws: A modification to the Jackson technique with intrasacral rods. Scoliosis 9: e17, 2014

Kobayashi Y, Iwanami A, Tsuji O, Takano M, Kimura T, Toyama Y, Nakamura M. Extramedullary non-myxopapillary ependymoma of the cauda equina; a case report and review of the literature. Journal of Spine & Neurosurgery 4: 2, 2014. (in press)

Nagoshi N, Suda K, Morita T, Matsumoto S, Iimoto S, Yasui K, Komatsu M, Kobayashi Y, Minami A, Toyama Y, Matsumoto M, Nakamura M. C1 posterior arch screw as an auxiliary anchor in posterior reconstruction for atlantoaxial dislocation associated with type II odontoid fracture: a case report and review of the literature. Springerplus. 3: 672, 2014. (in press)

Matsukawa K, Yato Y, Hynes RA, Imabayashi H, Hosogane N, Asazuma T, Toshiyasu M, Kobayashi Y, Nemoto K. Cortical bone trajectory for thoracic pedicle screws. Journal of Spinal Disorders & Techniques 26: e248-e253, 2014

Qin Y, Fu M, Takahashi M, Iwanami A, Kuga D, Rao RG, Sudhakar D, Huang T, Kiyohara M, Torres K, Dillard C, Inagaki A, Kasahara N, Goodglick L, Braun J, Mischel PS, Gordon LK, Wadehra M. Epithelial membrane protein-2 (EMP2) activates src and is a novel therapeutic target for glioblastoma. Journal of Biological Chemistry 289: 13974-13985, 2014

Nemoto O, Asazuma T, Yato Y, Imabayashi H, Yasuoka H, Fujikawa A. Comparison of fusion rates following transforaminal lumbar interbody fusion using polyetheretherketone cages or titanium cages with transpedicular instrumentation. European Spine Journal 23: 2150-2155, 2014

Satoh S, Yagi M, Machida M, Yasuda A, Konomi T, Miyake A, Fujiyoshi K, Kaneko S, Takemitsu M, Machida M, Yato Y, Asazuma T. Reoperation rate and risk factors of elective spinal surgery for degenerative spondylolisthesis ―Minimum 5 year follow-up―. Spine Journal 15: 1536-1544, 2014

Fujii T, Watanabe K, Toyama Y, Matsumoto M. Pulmonary function recovery demonstrated by ventilation-perfusion scan after posterior vertebral column resection for severe adolescent idiopathic scoliosis: a case report. Spine. 39: 1190-1194, 2014.(2.447)

Yoshimura N, Nagata K, Mukai D, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T. Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population; A 3-year follow-up of the ROAD study. Osteoporosis International 25: 1089-1098, 2014

Nakajima M, Takahashi A, Tsuji T, Karasugi T, Baba H, Uchida K, Kawabata S, Okawa A, Shindo S, Takeuchi K, Taniguchi Y, Maeda S, Kashii M, Seichi A, Nakajima H, Kawaguchi Y, Fujibayashi S, Takahata M, Tanaka T, Watanabe K, Kida K, Kanchiku T, Ito Z, Mori K, Kaito T, Kobayashi S, Yamada K, Takahashi M, Chiba K, Matsumoto M, Furukawa K, Kubo M, Toyama Y, Ikegawa S. A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine. Nature Genetics 46: 1012-1016, 2014. (29.648)

Wu Z, Iwanami A, Yasuda A, Mikami S, Toyama Y, Nakamura M. Intramedullary cervicothoracic subependymoma: report of three cases and review of the literature. Journal of Orthopaedic Science. 20: 927-934, 2014. (in press) (1.008)

Cao K, Watanabe K, Hosogane N, Toyama Y, Yonezawa I, Machida M, Yagi M, Kaneko S, Kawakami N, Tsuji T, Matsumoto M. Association of postoperative shoulder balance with adding-on in Lenke typeⅡ adolescent idiopathic scoliosis. Spine 39: 705-712, 2014

Nakamura M, Nishiwaki Y, Sumitani M, Ushida T, Yamashita T, Konno S, Taguchi T, Toyama Y. Investigation of chronic musculoskeletal pain(third report); With special reference to the importance of neuropathic pain and psychogenic pain. Journal of Orthopaedic Science 19: 667-675, 2014

Yagi M, Patel R, Lawhorne TW, Cunningham ME, Boachie-Adjei O. Adult thoracolumbar and lumbar scoliosis treated with long vertebral fusion to the sacropelvis: A comparison between new hybrid selective spinal fusion versus anterior-posterior spinal instrumentation. Spine Journal 14: 637-645, 2014

Yagi M, Rahm M, Gaines R, Maziad A, Ross T, Kim HJ, Kebaish K, Boachie-Adjei O. Characterization and surgical outcomes of proximal junctional failure in surgically treated patients with adult spinal deformity. Spine 39: 607-614, 2014

Kawaguchi Y, Matsumoto M, Iwasaki M, Izumi T, Okawa A, Matsunaga S, Chiba K, Tsuji T, Yamazaki M, Fujimori T, Yoshii T, Toyama Y. New classification system for ossification of the posterior longitudinal ligament using CT images. Journal of Orthopaedic Science. 19: 530-536, 2014. (1.008)

Yagi M, Hosogane N, Okada E, Watanabe K, Machida M, Tezuka M, Matsumoto M, Asazuma T. Factors affecting the postoperative progression of thoracic kyphosis in surgically treated adult patients with lumbar degenerative scoliosis. Spine 39: 521-528, 2014

Ishii K, Kaneko Y, Funao H, Ishihara S, Shinohara A, Nakanishi K, Hikata T, Fujita N, Iwanami A, Hosogane N, Watanabe K, Nagura T, Nakamura M, Toyama Y, Matsumoto M. A novel percutaneous guide wire (S-Wire) for pedicle screw insertion: Its development, efficacy, and safety. Surgical Innovation 22: 469-473, 2014

Nagoshi N, Iwanami A, Toyama Y, Nakamura M. Factors contributing to improvement of syringomyelia after foramen magnum decompression for Chiari type I malformation. Journal of Orthopaedic Science 19: 418-423, 2014. (1.008)

Nakamura Y, Nojiri K, Yoshihara H, Takahata T, Honda-Takahashi K, Kubo S, Sakatsume K, Kato H, Maruta T, Honda T. Significant differences of brain blood flow in patients with chronic low back pain and acute low back pain detected by brain SPECT. Journal Orthopaedic Science 19: 384-389, 2014

Nakamura M, Nishiwaki Y, Ushida T, Toyama Y. Prevalence and characteristics of chronic musculoskeletal pain in Japan; A second survery of people with or without chronic pain. Journal of Orthopaedic Science 19: 339-350, 2014

Boachie-Adjei O, Yagi M, Sacramento-Dominguez C, Akoto H, Cunningham ME, Gupta M, Hess WF, Lonner BS, Ayamga J, Papadopoulus E, Sanchez-Perez-Grueso F, Pelise F, Paonessa KJ, Kim HJ. Surgical risk stratification based on preoperative risk factors in severe pediatric spinal deformity surgery. Spine Deformity 2: 340-349, 2014

Cao K, Watanabe K, Kawakami N, Tsuji T, Hosogane N, Yonezawa I, Machida M, Yagi M, Kaneko S, Toyama Y, Matsumoto M. Selection of lower instrumented vertebra in treating Lenke type 2A adolescent idiopathic scoliosis. Spine 39: 253-261, 2014. (2.447)

Matsukawa K, Yato Y, Kato T, Imabayashi H, Asazuma T , Nemoto K. In vivo analysis of insertional torque during pedicle screwing using cortical bone trajectory technique. Spine 39: 240-245, 2014

Hikata T, Iwanami A, Hosogane N, Watanabe K, Ishii K, Nakamura M, Kamata M, Toyama Y, Matsumoto M. High preoperative hemoglobin A1c is a risk factor for surgical site infection after posterior thoracic and lumbar spinal instrumentation surgery. Journal of Orthopaedic Science 19: 223-228, 2014. (1.008)

Yagi M, Takeda K, Machida M, Asazuma T. Discordance of gravity line and C7PL in patient with adult spinal deformity-factors affecting the occiput-trunk suggittal discordance. Spine Journal 15: 213-221, 2014

Yagi M, Hasegawa A, Takemitsu M, Yato Y, Machida M, Asazuma T. Incidence and the risk factors of spinal deformity in adult patient after spinal cord injury: A single center cohort study. European Spine Journal 24: 203-208, 2014

Matsukawa K, Yato Y, Kato T, Imabayashi H, Asazuma T, Nemoto K. Cortical bone trajectory for lumbosacral fixation: Penetrating S-1 endplate screw technique. Journal of Neurosurgery Spine 21: 203-208, 2014

Iida T, Nakamura M, Tsuji O, Iwanami A, Mikami S, Toyama Y, Chiba K, Matsumoto M. Dumbbell mesenchymal chondrosarcoma: report of a rare case. Journal of Orthopaedic Science 19: 190-193, 2014

Nemani VM, Kim HJ, Bjerke-Kroll BT, Yagi M, Sacramento-Dominguez C, Akoto H, Papadopoulos EC, Sanchez-Perez-Grueso F, Pellise F, Nguyen JT, Wulff I, Ayamga J, Mahmud R, Hodes RM, Boachie-Adjei O. Preoperative halo-gravity traction for severe spinal deformities at An SRS-GOP site in West Africa: Protocols, complications, and results. Spine 40: 153-161, 2014

Yagi M, Iizuka S, Hasegawa A, Nagoshi N, Fujiyoshi K, Kaneko S, Takemitsu M, Shioda M, Machida M. Sagittal cervical alignment in adolescent idiopathic scoliosis. Spine Deformity 2: 122-130, 2014

Hikata T, Kamata M, Furukawa M. Risk factors for adjacent segment disease after posterior lumbar interbody fusion and efficacy of simultaneous decompression surgery for symptomatic adjacent segment disease. Journal of Spinal Disorders & Techniques 27: 70-75, 2014

Shinozaki M, Nakamura M, Konomi T, Kobayashi Y, Takano M, Saito N, Toyama Y, Okano H. Distinct roles of endogenous vascular endothelial factor receptor 1 and 2 in neural protection after spinal cord injury. Neuroscience Research 78: 55-64, 2014. (2.145)

Boachie-Adjei O, Yagi M, Nemani VM, Sacramento-Dominguez C, Akoto H, Cunningham ME, Gupta M, Hess WF, Lonner BS, Mendelow MJ, Papadopoulus EC, Sanchez-Perez-Grueso F, Pelise F, Paonesa K, Wright B, Wulff I, Kim HJ. Incidence and risk factors for major surgical complications in patients with complex spinal deformity: A report from an SRS GOP site. Spine Deformity 3: 57-64, 2014

Tanaka N, Konno S, Takeshita K, Fukui M, Takahashi K, Chiba K, Miyamoto M, Matsumoto M, Kasai Y, Kanamori M, Matsunaga S, Hosono N, Kanchiku T, Taneichi H, Hashizume H, Kanayama M, Shimizu T, Kawakami M. An outcome measure for patients with cervical myelopathy: the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): An average score of healthy volunteers. Journal of Orthopaedic Science 19: 33-48, 2014

Ishikawa M, Cao K, Pang L, Watanabe K, Yagi M, Hosogane N, Machida M, Shiono Y, Nishiyama M, Fukui Y, Matsumoto M. Postoperative behavior of thoracolumbar/lumbar curve and coronal balance after posterior thoracic fusion for Lenke 1C and 2C adolescent idiopathic scoliosis. Journal of Orthopaedic Science. 20: 31-37, 2014.(1.008)

Nagoshi N, Fehlings MG. Spinal cord concussion: Pathology and recommendation for return to play. Current Research: Concussion 1: 31-32, 2014

Theologis A, Tabaraee E, Funao H, Smith J, Burch S, Tay B, Kebaish K, Deviren V, Ames C. Three-column osteotomies of the lower cervical and upper thoracic spine: comparison of early outcomes, radiographic parameters, and peri-operative complications in 48 patients. European Spine Journal 24 Suppl 1: S23-30, 2014

Shirasawa H, Ishii K, Iwanami A, Mikami S, Toyama Y, Matsumoto M, Nakamura M. Pediatric myxopapillary ependymoma treated with subtotal resection and radiation therapy: A case report and review of the literature. Spinal Cord. 52: 18-20, 2014. (1.699)

Matsumoto M, Watanabe K, Hosogane N, Toyama Y. Updates on surgical treatments for pediatric scoliosis. Journal of Orthopaedic Science 19: 6-14, 2014

Kiriyama Y, Watanabe K, Matsumoto M, Toyama Y, Nagura T. Quantification of the spatial strain distribution of scoliosis using a thin-plate spline method. Journal of Biomechanics 47: 302-307, 2014. (2.496)

Tanaka N, Konno S, Takeshita K, Fukui M, Takahashi K, Chiba K, Miyamoto M, Matsumoto M, Kasai Y, Kanamori M, Matsunaga S, Hosono N, Kanchiku T, Taneichi H, Hashizume H, Kanayama M, Shimizu T, Kawakami M. An outcome measure for patients with cervical myelopathy: Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): An average score of healthy volunteers. J Orthop Sci 19: 33-48, 2014. (1.008)

Mori T, Sato Y, Miyamoto L, Kobayashi T, Shimizu T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Iwasaki T, Kawana H, Morioka H, Matsumoto M, Saya H, Toyama Y, Miyamoto T. TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state. Oncogene 33: 4236-4241, 2014. (8.559)

Kanagawa H, Niki Y, Kobayashi T, Sato Y, Katsuyama E, Fujie A, Hao W, Miyamoto K, Tando T, Watanabe R, Morita M, Morioka H, Matsumoto M, Toyama Y, Miyamoto T. Mycobacterium tuberculosis promotes arthritis development through toll-like receptor 2. Journal of Bone and Mineral Metabolism. [Epub ahead of print] (2.114)

Yagi M, Hosogane N, Okada E, Watanabe K, Machida M, Tezuka M, Matsumoto M, Asazuma T. Factors affecting the post operative progression of thoracic kyphosis in surgically treated adult patient with lumbar degenerative scoliosis. Spine 39: E521-528, 2014. (2.447)

Londono D, Kou I, Johnson TA, Sharma S, Ogura Y, Tsunoda T, Takahashi A, Matsumoto M, Herring JA, Lam TP, Wang X, Tam EMS, Song YQ, Fan YH, Chan D, Cheah KSE, Qiu X, Jiang H, Huang D, Japanese Scoliosis Clinical Research Group, TSRHC IS Clinical Group, the International Consortium for Scoliosis Genetics, Su P, Sham P, Cheung KMC, Luk KDK, Gordon1 D, Qiu Y, Cheng J, Tang N, Ikegawa S, Wise CA. A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. Journal of Medical Genetics 51: 401-406, 2014. (5.636)

Kakinuma H, Ishii K, Ishihama H, Honda M, Toyama Y, Matsumoto M, Aizawa M. Anti-bacterial polyetheretherketone implants immobilized with silver ions based on chelate-bonding ability of inositol phosphate: Processing, material characterization, cytotoxicity and anti-bacterial properties.Journal of Biomedical Materials Research Part A, 2014. [Epub ahead of print] ( 2.841)

Oh JK, Smith JS, Shaffrey CI, Lafage V, Schwab F, Ames CP, Matsumoto M, Baik JS, Ha Y. Sagittal spino-pelvic malalignment in Parkinson's disease: prevalence and associations with disease severity. Spine 39: E833-841, 2014. (2.447)

Cao K, Watanabe K, Hosogane N, Toyama Y, Yonezawa I, Machida M, Yagi M, Kaneko S, Kawakami N, Tsuji T, Matsumoto M. Association of postoperative shoulder balance with adding-on in Lenke type II adolescent idiopathic scoliosis. Spine 39: E705-712, 2014. (2.447)

Watanabe K, Uno K, Suzuki T, Kawakami N, Tsuji T, Yanagida H, Ito M, Hirano T, Yamazaki K, Minami S, Taneichi H, Imagama S, Takeshita K, Yamamoto T, Matsumoto M. Risk factors for proximal junctional kyphosis associated with dual-rod growing-rod surgery for early-onset scoliosis. Journal of Spinal Disorders and Techniques 2014. [Epub ahead of print] (1.888)

Matsumoto M, Hikata T, Iwanami A, Hosogane N, Watanabe K, Ishii K, Nakamura M, Toyama Y. Major complications and sequelae after total en bloc spondylectomy for malignant spinal tumors. Neurosurgery Quarterly. (in press) (0.089)

Choi HJ, Smith JS, Shaffrey CI, Lafage V, Schwab F, Ames CP, Matsumoto M, Baik JS, Ha Y. Coronal Plane Spinal Malalignment and Parkinson's Disease: Prevalence and Associations with Disease Severity. Spine Journal 2014. [Epub ahead of print] (2.8)

Nakayama R, Horiuchi K, Susa M, Watanabe I, Watanabe K, Tsuji T, Matsumoto M, Toyama Y, Morioka H. Clinical Outcome after Bone Metastasis (BM) Surgery in Patients with Differentiated Thyroid Carcinoma (DTC): A Retrospective Study of 40 Cases. Japanese Journal of Clinical Oncology. 2014. [Epub ahead of print] (1.747)

Yoshioka K, Ishii K, Kuramoto T, Nagai S, Funao H, Ishihama H, Shiono Y, Sasaki A, Aizawa M, Okada Y, Koyasu S, Toyama Y, Matsumoto M. A novel mouse model of soft-tissue infection using bioluminescence imaging allows noninvasive, real-time monitoring of bacterial growth. PLoS One 9: e106367, 2014. (3.534)

Sato Y, Miyauchi Y, Yoshida S, Morita M, Kobayashi T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Watanabe R, Miyamoto K, Morioka H, Matsumoto M, Toyama Y, Miyamoto T. The Vitamin D Analogue ED71 but Not 1, 25 (OH) 2D3 Targets HIF1α Protein in Osteoclasts. PLoS One: 9: e111845, 2014. (3.534)

Katsuyama E, Miyamoto H, Kobayashi T, Sato Y, Hao W, Kanagawa H, Fujie A, Tando T, Watanabe R, Morita M, Miyamoto K, Niki Y, Morioka H, Matsumoto M, Toyama Y, Miyamoto T. Interleukin-1 receptor-associated kinase-4 (IRAK4) promotes inflammatory osteolysis by activating osteoclasts and inhibiting formation of foreign body giant cells. Journal of Biological Chemistry 2014. [Epub ahead of print] (4.600)

Ishii K, Kaneko Y, Funao H, Ishihara S, Shinohara A, Nakanishi K, Hikata T, Fujita N, Iwanami A, Hosogane N, Watanabe K, Nagura T, Nakamura M, Toyama Y, Matsumoto M. A novel percutaneous guide wire (S-Wire) for percutaneous P pedicle screw insertion: Its development, efficacy, and safety. Surgical Innovation 2014. [Epub ahead of print] (1.338)

Okada E, Watanabe K, Pang L, Ogura Y, Takahashi Y, Hosogane N, Toyama Y, Matsumoto M: Posterior correction and fusion surgery using pedicle-screw constructs for Lenke type 5C adolescent idiopathic scoliosis. A preliminary report. Spine. (in press) (2.447)

Uchikawa S, Yoda M, Tohmonda T, Kanaji A, Matsumoto M, Toyama Y, Horiuchi K. ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface. Cytokine 71: 238-245, 2014. (2.874)

Okada E, Nakamura M, Koshida Y, Mukai K, Toyama Y, Matsumoto M. Breast carcinoma metastasis to meningioma in the thoracic spine: a case report and review of the literature. Journal of Spinal Cord Medicine (in press) (1.878)

Takano M, Kawabata S, Komaki Y, Shibata S, Hikishima K, Toyama Y, Okano H, Nakamura M. Inflammatory cascades mediate synapse elimination in spinal cord compression. J Neuro inflammation 11: 40, 2014. (4.902)

Zhang L, Kaneko S, Kikuchi K, Sano A, Maeda M, Kishino A, Shibata S, Mukaino M, Toyama Y, Liu M, Kimura T, Okano H, Nakamura M. Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition. Mol Brain 7: 14, 2014. (4.35)

Nakamura M, Nishiwaki Y, Ushida T, Toyama Y. Prevalence and chracteristics of chronic muscloskeletal pain in Japan: A second survery of people with or without chronic pain. J Orthop Sci 19: 339-350, 2014. (1.008)

Sumitani M, Yasunaga H, Uchida K, Horiguchi H, Nakamura M, Ohe K, Fushima K, Matsuda S, Yamada Y. Perioperative factors affecting the occurrence of acute complex regional pain syndrome following limb bone fracture surgery: Data from the Japanese Diagnosis Procedure Combination database. Rheumatology 53: 1186-1193, 2014. (4.435)

Nakamura M, Nishiwaki Y, Ushida T, Toyama Y. Prevalence and characteristics of chronic musculoskeletal pain in Japan: a second survey of people with or without chronic pain. J Orthop Sci 19: 339-350, 2014. (1.008)

Nakamura M, Nishiwaki Y, Sumitani M, Ushida T, Yamashita T, Konno S, Taguchi T, Toyama Y. Investigation of chronic musculoskeletal pain (third report): with special reference to the importance of neuropathic pain and psychogenic pain. J Orthop Sci 19: 667-675, 2014. (1.008)

Nishimura S, Sasaki T, Shimizu A, Yoshida K, Iwai H, Koya I, Kobayashi Y, Itakura G, Shibata S, Ebise H, Horiuchi K, Kudoh J, Toyama Y, Anderson AJ, Okano H, Nakamura M. Global gene expression analysis following spinal cord injury in non-human primates. Exp Neurol 261: 171-179, 2014. (4.617)

Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue. Focal transplantation of human iPSC-derived glial-rich neural progenitors improveslifespan of ALS mice.Stem Cell Reports 12: 242-249, 2014.

Sumitani M, Kogure T, Nakamura M, Shibata M, Yozu A, Otake Y, Yamada Y. Classification of the pain nature of CRPS type 1, based on patient complaints, into neuropathic pain and nociceptive/inflammatory pain, using the McGill Pain Questionnaire. J Anesthesia. (in press) (1.117)

Iwai H, Nori S, Nishimura S, Yasuda A, Takano O, Fujiyoshi K, Toyama Y, Okano H, Nakamura M. Transplantation of neural stem/progenitor cells at different locations in mice with spinal cord injury. Cell Transplant. (in press) (3.57)

Tashiro S, Shinozaki M, Mukaino M, Renault-Mihara F, Toyama Y, Liu M, Nakamura M, Okano H. BDNF Induced by Treadmill Training Contributes to the Suppression of Spasticity and Allodynia After Spinal Cord Injury via Upregulationof KCC2. Neurorehabil Neural Repair 2014. (in press) (4.617)

Itakura G, Kobayashi Y, Nishimura S, Iwai H, Takano M, Iwanami A, Toyama Y, Okano H, Nakamura M. Control of the survival and growth of human glioblastoma grafted into the spinal cord of mice by taking advantage of immunorejection. Cell transplantation. (in press) (3.57)

Nakamura M, Ushida T, Toyama Y. Reply to letter to the editor by Toda. J Orthop Sci 2014. (in press) (1.008)

Nishikawa R, Hotta R, Shimojima N, Shibata S, Nagoshi N, Nakamura M, Matsuzaki Y, Okano HJ, Kuroda T, Okano H, Morikawa Y. Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung's disease. Cytotechnology 2014. (in press) (1.449)

Iwanami A, Kobayashi Y, Takano M, Mikami S, Toyama Y, Nakamura M. Invasive dumbbell spinal meningiomas: report of four cases and a review of the literature. J Orthop Sci 2014. (in press) (1.008)

Itakura G, Kobayashi Y, Nishimura S, Iwai H, Takano M, Iwanami A, Toyama Y, Okano H, Nakamura M. Controlling immune rejection is a fail-safe system against potential tumorigenicity after human iPSC-derived neural stem cell transplantation. PLoS One 2014. (in press) (3.534)

Nori S, Okada Y, Nishimura S, Sasaki T, Itakura G, Kobayashi Y, Renault-Mihara F, Shimizu A, Koya I, Yoshida R, Kudoh J, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Nakamura M, Okano H. Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition. Stem Cell Reports 2014. (in press)

Matsui T, Akamatsu W, Nakamura M, Okano H. Regeneration of the damaged central nervous system through reprogramming technology: basic concepts and potential application for cell replacement therapy. Exp Neurol 260: 12-18, 2014. (4.617)

Qin Y, Fu M, Takahashi M, Iwanami A, Kuga D, Rao RG, Sudhakar D, Huang T, Kiyohara M, Torres K, Dillard C, Inagaki A, Kasahara N, Goodglick L, Braun J, Mischel PS, Gordon LK, Wadehra M. Epithelial membrane protein-2 (emp2) activates src and is a novel therapeutic target for gbm. The Journal of biological chemistry. 2014. (in press) (4.600)

Fujita N, Hirose Y, Tran CM, Chiba K, Miyamoto T, Toyama Y, Shapiro IM, Risbud MV. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. FASEB J. 6: 2455-65, 2014. (5.480)

Nishimon M, Shimizu Y, Ueno M, Iwanami A. Late-onset congenital lateral dermal sinus tract. BMJ Case Rep. 2014. (in press)

Iwanami A, Toyama Y. Cervical spondylosis. Nihon rinsho. Japanese journal of clinical medicine 72: 1755-1760, 2014.

PAGETOP