DEPARTMENT OF ORTHOPAEDIC SURGERY

  • GREETING
  • STAFF
  • SPINE AND SPINAL CORD DIVISION
  • UPPER EXTREMITY DIVISION
  • LOWER EXTREMITY DIVISION
  • ORTHOPAEDIC ONCOLOGY DIVISION
  • BASIC AND LABORATORY
  • RESIDENT

JAPANESE

ORTHOPAEDIC ONCOLOGY DIVISION

Bone and soft tissue tumors are uncommon in orthopaedic practices, and therefore patients need specialized care by specialists who are well trained for both bone and soft tissue tumors. We have approximately 350 surgical cases each year which include limb salvage surgery for malignant bone and soft tissue tumors and CT guided resection of benign bone tumors such as osteoid osteoma. We are currently performing multiple translational researches such as the utilization of gene expression for diagnosis and identifying new molecular targets and biologics for the treatment of sarcomas.

STAFF

Hideo Morioka, MD

Associate Professor
Graduate Year1988
SpecialtyBone and soft tissue tumors (pediatrics and adults), Chemotherapy for malignant bone and soft tissue tumors, Minimum invasive treatment of bone and soft tissue tumors
Study in AbroadUniversity of Vienna (Austria)
Harvard University (USA)

Keisuke Horiuchi, MD

Associate Professor
Graduate Year1994
Study in AbroadMemorial Sloan Kettering Cancer Center (USA)
Cornell University, Hospital for Special Surgery (USA)

Robert Nakayama, MD

Instructor
Graduate Year 2001
SpecialtyBone and soft tissue tumors
Study in Abroad Medical University of Vienna

Harvard University Dana-Farber Cancer Institute


Kazutaka Kikuta, MD

Instructor
Graduate Year2002
SpecialtyBone and Soft tissue tumors (pediatrics and adults), Chemotherapy for malignant bone and soft tissue tumors, P Surgical reconstruction following resection of bone and soft tissue tumors, Proteomics
Study in AbroadCochin Hospital (France)

PAGETOP

PROJECTS

Surgical reconstruction following resection of osteosarcoma

We perform chemotherapy before and after surgical resection and reconstruction of osteosarcoma. In majority of the cases, we perform limb savage surgery for malignant bone and soft tumors instead of amputation. Special tumor prosthesis or biological reconstruction using pasteurized autogenous bone graft are commonly used for many cases.

Osteosarcoma of the pelvis

Autogenous bone graft using liquid nitrogen

We use liquid nitrogen to induce cell death of tumor cells and reimplant the bone graft following wide resection. (A case with adamantinoma is presented as a representative case)

Cryotherapy for malignant bone and soft tissue tumor

Since 2011, we have performed cryotherapy for advanced stage (metastatic stage) malignant bone and soft tissue tumors. This technique can be used for the tumor within 5 cm, and hospital stay will be 2-3 days.

CT guided resection of osteoid osteoma

Since 1995, we have performed CT guided resection of osteoid osteoma. This minimum invasive procedure provide early recovery of the patients and decreased postoperative pain due to the small incision.

Pre-surgical marking using MRI to reduce incision for high invasive soft tissue sarcoma

Soft tissue sarcoma is known to be very progressive and has high recurrence rate. We use pre-surgical marking using MRI for these sarcomas, and it enables us to reduce surgical margin.

Proteomics analysis to develop biomarkers related to high invasive activity on myxofibrosarcoma

With collaboration with National Cancer Center Institute in Japan, we investigate a novel approach to analyze distribution of tumor protein in malignant soft tissue tumor, such as myxofibrosarcoma.

REFERENCES (IMPACT FACTOR)

Yamaguchi Iwai S, Ueki A, Sugihara E, Onishi N, Yaguchi T, Kawakami Y, Morioka H, Matsumoto M, Nakamura M, Mutoh A, Toyama Y, Saya H, Shimizu T. Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells. Cancer Science 106: 875-882, 2015

Udaka T, Susa M, Kikuta K, Nishimoto K, Horiuchi K, Sasaki A, Kameyama K, Nakamura M, Matsumoto M, Chiba K, Morioka H. Langerhans Cell Histiocytosis of the Clavicle in an Adult: A Case Report and Review of the Literature. Case Reports in Oncology 8(3): 426-431, 2015

Aoyagi T, Morii T, Tajima T, Yoshiyama A, Ichimura S. Analysis of the risk factors for febrile neutropenia in patients with bone and soft tissue sarcoma. Anticancer Research 35: 2375-2383, 2015

Morii T, Aoyagi T, Tajima T, Yoshiyama A, Ichimura S, Mochizuki K. Unplanned resection of a soft tissue sarcoma: clinical characteristics and impact on oncological and functional outcomes. Journal of Orthopaedic Science (JOS) 20: 373-379, 2015

Morii T, Tajima T, Aoyagi T, Ichimura S. D-dimer Level Changes During Systemic Chemotherapy Can Predict Prognosis of High-grade Musculoskeletal Sarcoma Patients. Anticancer Research 35: 6781-6786, 2015

Irimura S, Nishimoto K, Kikuta K, Nakayama R, Susa M, Horiuchi K, Nakamura M, Matsumoto M, Morioka H. Successful Treatment with Pazopanib for Multiple Lung Metastases of Inguinal Epithelioid Sarcoma: A Case Report. Case Reports in Oncology 8(3): 378-384

Kinoshita T, Kamiyama I, Hayashi Y, Asakura K, Ohtsuka T, Kohno M, Emoto K, Nakayama R, Morioka H, Asamura H. Spontaneous Regression of Metastatic Extraskeletal Myxoid Chondrosarcoma. Annals of Thoracic Surgery Volume 100: 1465-1467, 2015

Hirozane T, Suzuki T, Yoshida H. Pycnodysostosis with a patella fracture. Lancet Diabetes & Endocrinology 10: 826, 2015

Hosaka S, Katagiri H, Wasa J, Murata H, Takahashi M. Solitary fibrous tumor in the pelvis: induced hypoglycemia associated insulin-like growth factor II. Journal of Orthopaedic Science (JOS) 20: 439-443, 2015

Susa M, Oguro S, Kikuta K, Nishimoto K, Horiuchi K, Jinzaki M, Nakamura M, Matsumoto M, Chiba K, Morioka H. Novel MR imaging method - MAVRIC - for metal artifact suppression after joint replacement in musculoskeletal tumor patients. BMC Musculoskeletal Disorder 16: 377, 2015

Setsu N, Kobayashi E, Naofumi A, Yasui N, Kawamoto H, Kawai A, Horiuchi K. Severe hypercalcemia following denosumab treatment in a juvenile patient. Journal of Bone and Mineral Research (JBMR) 34: 118-122, 2015

Koba T, Susa M, Nakayama R, Watanabe I, Horiuchi K, Mukai M, Yabe H, Toyama Y, Morioka H. Desmoplastic fibroma arising in the distal phalanx of the great toe: a case report. Foot and Ankle Surgery 53: 71-74, 2015

Nishida Y, Kobayashi E, Kubota D, Setsu N, Ogura K, Tanzawa Y, Nakatani F, Kato Y, Chuman H, Kawai A. Chronic expanding hematoma with a significantly high fluorodeoxyglucose uptake on 18F-fluorodeoxyglucose positron emission tomography, mimicking a malignant soft tissue tumor: a case report. Journal of Medical Case Reports. 8: 349, 2014. (0.40)

Yoshiyama A, Morii T, Tajima T, Aoyagi T, Honya K, Mochizuki K, Satomi K, Ichimura S. D-dimer levels in the differential diagnosis between lipoma and well-differentiated liposarcoma. Anticancer Research. 34: 5181-5185. 2014. (1.872)

AsanoN, Yoshida A, Ogura K, Kobayashi E, Susa M, Morioka H, Iwata S, Ishii T, Hiruma T, Chuman H, Kawai A. Prognostic value of relevant clinicopathologic variables in epithelioid sarcoma: a multi-institutional retrospective study of 44 patients. Annals of Surgical Oncology. 22: 2624-2632, 2014. (3.943)

Asano N, Yoshida A, Kobayashi E, Yamaguchi T, Kawai A. Multiple metastases from histologically benign intraarticular diffuse-type tenosynovial giant cell tumor: a case report. Human Pathology. 2014 Nov; 45: 2355-2358. (2.81)

Fukunaga Y, Miyamoto S, Kobayashi E, Sakuraba M. Venous-supercharged free-style posterior thigh flap without a descending branch of the inferior gluteal artery for reconstruction in the infragluteal region. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2014 Dec; 67: 1740-1743. (1.47)

Kobayashi E, Koyama T, Kobayashi K, Setsu N, Kawashima M, Kawai A. Reversible hair depigmentation in a Japanese female treated with pazopanib. Journal of Dermatology. 41: 1021-1022. (2.35)

Miyamoto S, Kayano S, Kamizono K, Fukunaga Y, Nakao J, Nakatani F, Kobayashi E, Sakuraba M. Pedicled superficial femoral artery perforator flaps for reconstruction of large groin defects. Microsurgery. 34: 470-474, 2014.(1.62)

Yoshida A, Asano N, Kawai A, Kawamoto H, Nakazawa A, Kishimoto H, Kushima R. Differential SALL4 immunoexpression in malignant rhabdoid tumours and epithelioid sarcomas. Histopathology. 66: 252-261, 2014.(3.301)

Yamazaki F, Osumi T, Shigematsu N, Morioka H, Shimada H. Successful treatment of metastatic rhabdomyosarcoma with radiochemotherapy and allogeneic hematopoietic stem cell transplantation. Japanese Journal of Clinical Oncology 45: 225-228, 2014

Kikuta K, Kubota D, Yoshida A, Morioka H, Toyama Y, Chuman H, Kawai A. An analysis of factors related to the tail-like pattern of myxofibrosarcoma seen on MRI. Skeletal Radiology 44: 55-62, 2014

Nakayama R, Horiuchi K, Susa M, Watanabe I, Watanabe K, Tsuji T, Matumoto M, Toyama Y, Morioka H. Clinical outcome after bone metastasis (BM) surgery in patients with differentiated thyroid carcinoma (DTC): a retrospective study of 40 cases. Japanese Journal of Clinical Oncology 44: 918-925, 2014

Fukuda S, Susa M, Watanabe I, Nishimoto K, Horiuchi K, Toyama Y, Morioka H. Computed tomography-guided resection of osteoid osteoma of the sacrum: a case report. Journal of Medical Case Reports 8, 2014

Mori T, Sato Y, Miyamoto K, Kobayashi T, Shimizu T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Watanabe R, Morita M, Iwasaki R, Kawana H, Morioka H, Matsumoto M, Saya H, Toyama Y, Miyamoto T. TNFa promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state. Oncogene 33: 4236-4241, 2014

Odagiri H, Kadomatsu T, Endo M, Masuda T, Morioka MS, Fukuhara S, Miyamoto T, Kobayashi E, Miyata K, Aoi J, Horiguchi H, Nishimura N, Terada K, Yakushiji T, Manabe I, Mochizuki N, Mizuta H, Oike Y. The Secreted Protein ANGPTL2 Promotes Metastasis of Osteosarcoma Cells through Integrin α5β1, p38 MAPK, and Matrix Metalloproteinases. Science Signaling. 7: ra7, 2014. (7.65)

Mori T, Sato Y, Miyamoto K, Kobayashi T, Shimizu T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Iwasaki R, Kawana H, Morioka H, Matsumoto M, Saya H, Toyama Y, Miyamoto T. TNFαpromotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state. Oncogene 33: 4236-4241, 2014

Matsushima S, Ohtsuka K, Ohnishi H, Fujiwara M, Nakamura H, Morii T, Goto H, Watanabe T. V843I, a lung cancer predisposing EGFR mutation, is responsible for resistance to EGFR tyrosine kinase inhibitors. Journal of Thorac Oncology. 9: 1377-1384. 2014. (5.8)

Fujiwara T, Katsuda T, Hagiwara K, Kosaka N, Yoshioka Y, Takahashi R, Takeshita F, Kubota D, Kondo T, Ichikawa H, Yoshida A, Kobayashi E, Kawai A, Ozaki T, Ochiya T. Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells. Stem Cells. 32: 959-973, 2014. (7.70)

Kikuta K, Morioka H, Kawai A, Kondo T. Global protein-expression profiling for reclassification of malignant fibrous histiocytoma. Biochimica et Biophysica Acta - Proteins & Proteomics 1854: 696-701, 2014

Mukaihara K, Kubota D, Yoshida A, Asano N, Suehara Y, Kaneko K, Kawai A, Kondo T. Proteomic profile of epithelioid sarcoma. Journal of Proteomics & Bioinformatics. 7: 158-165, 2014.

Kobayashi E, Satow R, Ono M, Masuda M, Honda K, Sakuma T, Kawai A, Morioka H, Toyama Y, Yamada T. MicroRNA expression and functional profiles of osteosarcoma. Oncology. 18; 86: 94-103, 2014. (2.1)

Huang G, Nishimoto K, Yang Y, Kleinerman ES. Participation of the Fas/FasL signaling pathway and the lung microenvironment in the development of osteosarcoma lung metastases. Advances in Experimental Medicine and Biology. 64: 30-36, 2014. (2.012)

Kubota D, Yoshida A, Kikuta K, Saito T, Suehara Y, Gotoh M, Kawai A, Kondo T. Proteomic approach to gastrointestinal stromal tumor identified prognostic biomarkers. Proteomics and Bioinformatics 7: 10-16, 2014

Yamaguchi K, Yanagimoto S, Kageyama T, Fujita Y, Funayama A, Kanaji A, Susa M, Toyama Y. Experimental assessment of a novel intramedullary nail for callus distraction by the segmental bone transport method. J Orthop Sci. 2014 Mar; 19(2): 323-31. (1.008)

Mori T, Sato Y, Miyamoto K, Kobayashi T, Shimizu T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Tando T, Iwasaki R, Kawana H, Morioka H, Matsumoto M, Saya H, Toyama Y, Miyamoto T. TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state. Oncogene. 2014 Aug 14; 33(33): 4236-41. (8.559)

Kobayshi E, Setsu N. Osteosclerosis Induced by Denosumab. Lancet. 2014 Oct 28. pii: S0140-6736(14) 61338-6. [Epub ahead of print]. (39.21)

Morii T, Ohtsuka K, Ohnishi H, Mochizuki K, Yoshiyama A, Aoyagi T, Hornicek FJ, Ichimura S. BH3 mimetics inhibit growth of chondrosarcoma--a novel targeted-therapy for candidate models. Anticancer Res 34: 6423-6430. 2014. (1.872)

Morii T, Aoyagi T, Tajima T, Yoshiyama A, Ichimura S, Mochizuki K. Unplanned resection of a soft tissue sarcoma: Clinical characteristics and impact on oncological and functional outcomes. J Orthop Sci. (In press) (1.008)

Aoyagi T, Morii T, Tajima T, Yoshiyama A, Ichimura S. Analysis of the Risk Factors for Febrile Neutropenia in Patients with Bone and Soft Tissue Sarcoma. Anticancer Res. (In press) (1.872).

PAGETOP